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At Boston Children's Hospital, where I am an Associate Professor in the Department of Surgery at Harvard Medical School, my group uncovered crucial function of endothelial cell-specific or lymphatic endothelial cell-specific epsins in the regulation of VEGF signaling through the internalization and degradation of its respective VEGFR2 or VEGFR3 receptor (Pasula, et al. JCI, 2012; Tessneer, et al. ATVB, 2014; Liu, et al. Science Signaling, 2014; Dong, et al. JCI, 2015; Rahman, et al. Cir. Res, 2016; Wu, et al. JCI, 2018; Brophy, et al. Cir. Res, 2019; Dong, et al. Nature Comm, 2020). Epsin loss dramatically impaired VEGFR2 and VEGFR3 downregulation resulting in heightened angiogenesis and lymphangiogenesis, respectively.


Date Time Room Session/Title Presentation
Time
Presentation Title Role
Sep. 9 (Wed) 16:00-18:00 Room 2 Symposium 06
Vascular Signaling
16:40-17:00 Endocytic Adaptor Epsin Is a Gatekeeper of Quiescent Endothelium Speaker


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