- Goethe University Frankfurt
Altered endothelial cell function is recognized as the initiating event of many cardiovascular and metabolic diseases. We study global changes in endothelial cell signaling pathways essential for the regulation of vascular homeostasis and the initiation and progression of cardiovascular and metabolic diseases, making use of cutting-edge transcriptomic, proteomic and metabolomic technologies. Ongoing studies investigate the relevance and mechanisms of action of selected small open reading frame-encoded microproteins following endothelial cell activation and in cardiovascular disease as well as vascular repair. Another research area investigates the biology of the endothelial nitric oxide synthase and nitric oxide signaling.
|Sep. 9 (Wed)
||(Short Talk) Tyrosine Phosphorylation of eNOS Regulates Endothelial Function and Endothelial Redox Homeostasis