Berislav V. Zlokovic
- Keck School of Medicine of USC
I study the role of cerebral blood vessels in the pathogenesis and treatment of Alzheimer’s disease (AD) and stroke. We found that dysfunction in the blood-brain barrier (BBB) can precede neuronal dysfunction in both synapses and nerve cells contributing to neurodegeneration, cognitive impairment and AD pathology. This includes the cellular and molecular mechanisms in cerebral blood vessels underlying neuronal dysfunction, and pathways that maintain homeostasis of Alzheimer’s amyloid-beta toxin. We have developed advanced neuroimaging methods and molecular biomarkers to study BBB integrity in the living human brain. These findings contributed to Phase 2/3 clinical trials in AD and stroke.
|Sep. 9 (Wed)
||Blood-Brain Barrier Dysfunction Predicts Cognitive Decline in Alzheimer’s Disease: Effect of the APOE4 Gene